The Tuam Bypass will be closed overnight for just under a month while upgrade works are being carried out in September.
The road will be shut nightly between Junction 20 and the Ballygaddy Road Junction.
The closure will be in place from 8pm each evening until 6am the following morning.
This will begin on Monday, September 8, and continue each night until Saturday, October 4.
The closure is to allow for the installation of loops and sensors for a new weigh-in motion station for TII.
Alternate routes will be available via the R939 through Tuam town and R332 Ballygaddy Road.